The effect of intrauterine insemination preceding frozen-thawed elective single embryo transfer in couples with unexplained subfertility

The effect of intrauterine insemination preceding frozen-thawed elective single embryo transfer in couples with unexplained subfertility

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Introduction This prospective randomized controlled trial aimed to evaluate the effect of intrauterine insemination (IUI) before frozen-thawed elective single embryo transfer (FT-eSET).Material and methods A total of 200 couples with unexplained subfertility underwent in-vitro fertilization (IVF) treatment.Patients were randomly assigned to either FT-eSET or IUI preceding FT-eSET.

Both groups were composed of 100 women.IUI was timed 6 days before FT-eSET in the IUI preceding FT-eSET group.Implantation rates (IR), biochemical and clinical abortion rates (AR), clinical pregnancy rates (PR), ongoing pregnancy rates (PRs), and live GARLIC-ALLICIN birth rates were measured in this study.

Results The IUI preceding FT-eSET group was associated with higher rates of clinical pregnancy, 54% vs.42%, but not significantly.Similarly, IR, PR and live birth rate were higher in Visors the IUI preceding FT-eSET group but not significantly.

In the IUI preceding FT-eSET group, the biochemical and clinical abortion rates were lower than in the control group (9.5% vs.14.

2% and 5.5% vs.5.

2%, respectively).However, no statistically significant difference was found between the two groups, either.Conclusions This is the first study showing that IUI may precede FT-eSET to improve PR in couples with unexplained subfertility.

Also, performing IUI before FT-eSET may decrease biochemical and clinical abortion rates.